Toy Story 3 (PS3, Xbox 360, Wii)
Red Dead Redemption (Xbox 360, PS3)
Lego Harry Potter: Years 1-4 (PS3, Xbox 360, PC, DS, Wii, PSP)
Dance on Broadway (Wii)
Crackdown 2 (Xbox 360)
The entry to fifth for Toy Story 3 is a little lower than I had expected for the Disney tie-in game. Take a look at my review for my impressions on the game. Crackdown 2 stays top for the second week running in a long, barren spell for videogame releases.
It's been at least 10 years coming, but Starcraft finally gets it sequel this week with Starcraft II: Wings of Liberty. It should make it into the top five, perhaps the top three.